Sunday, July 13, 2014

How Well Do You Know Syphilis?

Know a lot more about one of the most common STDs worldwide.

Syphilis is the third most common sexually transmitted disease (STD), caused by treponema pallidum. It is known to be a multi-organ system disease. Its other names are "pox", "lues", or "bad blood disease". Its incubation period is usually10-70 days with an average of 21 days; of course this is after contact. Disease transmission is acquired through having sexual contact, and/or through blood transmission. It could also be congenital in such cases of placental transmission which happens after 5 months of gestation. But in reported cases, sexual transmission is still rather rampant.




There are four known stages of acquired Syphilis:



Primary stage


 In this stage, there is the appearance of a painless lesion or chancre, the indurated lesions heal spontaneously with or without treatment. Usually lasts 4-6 weeks. Other infected people might disregard this early stage and the chancre per se, assuming that it is just as ordinary skin ulcer that would just fade away. Well, think again, although this is not painful, it is an early indication for treatment.

Secondary stage


This is considered as the most contagious stage which lasts 6-8 weeks. Strict precautions must be observed. There would be an appearance of non-itchy generalized rash involving the palms and soles, with papular lesions. Again, if just based on appearance, the infected might think of it as another different condition. Proper knowledge and appropriate diagnosis and intervention is still vital. The infected person would also experience changes in hair growth like patchy alopecia, which is characterized by a "moth eaten appearance". There would also be arthritic pain and lymphadenopathy or any disease of the lymph glands.

Latent stage


This occurs within 1-2 yrs, and without any presence of clinical signs and symptoms.

Tertiary stage


This is also known as the late stage of syphilis. There would be an appearance of localized mass (gumma) that may be found in almost any organ of the body. Most cases that have been neglected might end up to this stage wherein there is already a possible massive spread of lesions all over the body.



DIAGNOSIS

Screening tests are done in order to determine the presence of Syphilis, and would detect antibodies to the bacterium that causes the said disease.
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  1. 1. Venereal Disease Research Laboratory (VDRL) test

  1.     Although sometimes not accurate and can’t be done in very early or advanced stages, it can still help determine and check antibodies present in people who have contacted the disease. This is done either on a sample of blood or spinal fluid.


             2. Rapid Plasma Rengin (RPR)

          Just like the test above, the RPR test also detects antibodies.

             3. Enzyme immunoassay (EIA) test

          Another blood test that checks for antibodies. If positive with the         EIA test, another confirmatory test through either VDRL or RPR             should be done.

Confirmatory tests are also done in order to diagnose Syphilis:

               1. Fluorescent treponemal antibody absorption (FTA-ABS) test

                   Same as the screening tests, this can also check the presence of                    antibodies to the syphilis bacteria however except during the first 3                to 4 weeks after exposure to syphilis bacteria. This is also through                blood sample and spinal fluid.

               2. Treponema pallidum particle agglutination assay (TPPA)

                   This is a test done to confirm Syphilis after other tests methods                    resulted positive.

               3. Darkfield microscopy

                   This is a recommended method to be used in early stage of the                      disease. It uses a special microscope to detect the presence of                      syphilis on fluid or tissue sample from a chancre.

               4. Microhemagglutination assay (MHA-TP) 

                   Just the same as other confirmatory tests, this is also used to                      confirm syphilis after other test methods turns out positive.


Can Syphilis be treated?


Yes, it can. Penicillin G is usually the drug of choice as treatment for primary and secondary stages of syphilis. Penicillin is a widely used antibiotic; this is usually administered as injection and is considered effective. However, like most injectable antibiotics, a skin test would be required to test for any possible allergic reactions. Since some people are indeed allergic to Pen G, they are treated with a different oral antibiotic, such as tetracycline.


        Before engaging into any sexual acts with your flaring libido, always remember to stay safe and use appropriate protection. You can never be too sure.





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